Ontology highlight
ABSTRACT:
SUBMITTER: Redmond SA
PROVIDER: S-EPMC4990461 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Redmond Stephanie A SA Mei Feng F Eshed-Eisenbach Yael Y Osso Lindsay A LA Leshkowitz Dena D Shen Yun-An A YA Kay Jeremy N JN Aurrand-Lions Michel M Lyons David A DA Peles Elior E Chan Jonah R JR
Neuron 20160804 4
Myelination occurs selectively around neuronal axons to increase the efficiency and velocity of action potentials. While oligodendrocytes are capable of myelinating permissive structures in the absence of molecular cues, structurally permissive neuronal somata and dendrites remain unmyelinated. Utilizing a purified spinal cord neuron-oligodendrocyte myelinating co-culture system, we demonstrate that disruption of dynamic neuron-oligodendrocyte signaling by chemical cross-linking results in aberr ...[more]