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Hydrodynamic dispensing and electrical manipulation of attolitre droplets.

ABSTRACT: Dispensing and manipulation of small droplets is important in bioassays, chemical analysis and patterning of functional inks. So far, dispensing of small droplets has been achieved by squeezing the liquid out of a small orifice similar in size to the droplets. Here we report that instead of squeezing the liquid out, small droplets can also be dispensed advantageously from large orifices by draining the liquid out of a drop suspended from a nozzle. The droplet volume is adjustable from attolitre to microlitre. More importantly, the method can handle suspensions and liquids with viscosities as high as thousands mPa?s markedly increasing the range of applicable liquids for controlled dispensing. Furthermore, the movement of the dispensed droplets is controllable by the direction and the strength of an electric field potentially allowing the use of the droplet for extracting analytes from small sample volume or placing a droplet onto a pre-patterned surface.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC4990644 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Hydrodynamic dispensing and electrical manipulation of attolitre droplets.

Zhang Yanzhen Y Zhu Benliang B Liu Yonghong Y Wittstock Gunther G

Nature communications 20160812

Dispensing and manipulation of small droplets is important in bioassays, chemical analysis and patterning of functional inks. So far, dispensing of small droplets has been achieved by squeezing the liquid out of a small orifice similar in size to the droplets. Here we report that instead of squeezing the liquid out, small droplets can also be dispensed advantageously from large orifices by draining the liquid out of a drop suspended from a nozzle. The droplet volume is adjustable from attolitre ...[more]

PMID: 27514279

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