Comprehensive Assessment of the Association between FCGRs polymorphisms and the risk of systemic lupus erythematosus: Evidence from a Meta-Analysis.

ABSTRACT: We performed a meta analysis to assess the relationship of FCGRs polymorphisms with the risk of SLE. Thirty-five articles (including up to 5741 cases and 6530 controls) were recruited for meta-analysis. The strongest association was observed between FCGR2B rs1050501 and SLE under the recessive genotypic model of C allele in the overall population (CC vs CT/TT, OR?=?1.754, 95%CI: 1.422-2.165, P?=?1.61?×?10(-7)) and in Asian population (CC vs CT/TT, OR?=?1.784, 95%CI; 1.408-2.261, P?=?1.67?×?10(-6)). We also found that FCGR3A rs396991 were significant association with the susceptibility to SLE in overall population in recessive model of T allele (TT vs TG/GG, OR?=?1.263, 95%CI: 1.123-1.421, P?=?9.62?×?10(-5)). The results also showed that significant association between FCGR2A rs1801274 and SLE under the allelic model in the overall population (OR?=?0.879 per A allele, 95%CI: 0.819-0.943, P?=?3.31?×?10(-4)). The meta-analysis indicated that FCGR3B copy number polymorphism NA1·NA2 was modestly associated with SLE in overall population (OR?=?0.851 per NA1, 95%CI: 0.772-0.938, P?=?1.2?×?10(-3)). We concluded that FCGR2B rs1050501 C allele and FCGR3A rs396991 T allele might contribute to susceptibility and development of SLE, and were under recessive association model. While, FCGR2A rs1801274 A allele and FCGR3B NA1 were associated with SLE and reduced the risk of SLE.

SUBMITTER: Zhu XW 

PROVIDER: S-EPMC4990922 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature