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Facile solid phase peptide synthesis with a Re-lysine conjugate generated via a one-pot procedure.

ABSTRACT: We have synthesized a Re(CO)3-modified lysine via a one-pot Schiff base formation reaction that can be used in the solid phase peptide synthesis. To demonstrate its potential use, we have attached it to a neurotensin fragment and observed uptake into human umbilical vascular endothelial cells.

SUBMITTER: Chanawanno K 

PROVIDER: S-EPMC4991030 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Facile solid phase peptide synthesis with a Re-lysine conjugate generated via a one-pot procedure.

Chanawanno Kullapa K   Caporoso Joel J   Kondeti Vinay V   Paruchuri Sailaja S   Leeper Thomas C TC   Herrick Richard S RS   Ziegler Christopher J CJ  

Dalton transactions (Cambridge, England : 2003) 20140530 30

We have synthesized a Re(CO)3-modified lysine via a one-pot Schiff base formation reaction that can be used in the solid phase peptide synthesis. To demonstrate its potential use, we have attached it to a neurotensin fragment and observed uptake into human umbilical vascular endothelial cells. ...[more]

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