Ontology highlight
ABSTRACT:
SUBMITTER: Komaragiri SK
PROVIDER: S-EPMC4991035 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Komaragiri Shravan Kumar SK Bostanthirige Dhanushka H DH Morton Derrick J DJ Patel Divya D Joshi Jugal J Upadhyay Sunil S Chaudhary Jaideep J
Biochemical and biophysical research communications 20160725 1
Deregulation of tumor suppressor genes is associated with tumorigenesis and the development of cancer. In prostate cancer, ID4 is epigenetically silenced and acts as a tumor suppressor. In normal prostate epithelial cells, ID4 collaborates with androgen receptor (AR) and p53 to exert its tumor suppressor activity. Previous studies have shown that ID4 promotes tumor suppressive function of AR whereas loss of ID4 results in tumor promoter activity of AR. Previous study from our lab showed that ect ...[more]