Ontology highlight
ABSTRACT:
SUBMITTER: Menard C
PROVIDER: S-EPMC4991373 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Ménard Catherine C Rezende Flavio A FA Miloudi Khalil K Wilson Ariel A Tétreault Nicolas N Hardy Pierre P SanGiovanni John Paul JP De Guire Vincent V Sapieha Przemyslaw P
Oncotarget 20160401 15
Age-related macular degeneration (AMD) is a leading cause of blindness worldwide affecting individuals over the age of 50. The neovascular form (NV AMD) is characterized by choroidal neovascularization (CNV) and responsible for the majority of central vision impairment. Using non-biased microRNA arrays and individual TaqMan qPCRs, we profiled miRNAs in the vitreous humour and plasma of patients with NV AMD. We identified a disease-associated increase in miR-146a and a decrease in miR-106b and mi ...[more]