Ontology highlight
ABSTRACT:
SUBMITTER: Marinelli M
PROVIDER: S-EPMC4991472 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Marinelli Marilisa M Ilari Caterina C Xia Yi Y Del Giudice Ilaria I Cafforio Luciana L Della Starza Irene I Raponi Sara S Mariglia Paola P Bonina Silvia S Yu Zhen Z Yang Wenjuan W Qiu Lugui L Chan Thomas T Piciocchi Alfonso A Kwong Yok-Lam YL Tse Eric E Li Jianyong J Guarini Anna A Xu Wei W Foà Robin R
Oncotarget 20160401 15
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in the Western world, whereas in Asia the incidence is about 10 times lower. The basis for this ethnic and geographic variation is currently unknown. The aim of this study was to characterize IGHVDJ rearrangements and stereotype of the HCDR3 region in a series of 623 Chinese CLL, in order to identify possible differences in immunoglobulin gene usage and their potential pathogenetic implications. Chinese CLL were compared to 7 ...[more]