Ontology highlight
ABSTRACT:
SUBMITTER: Hsu TI
PROVIDER: S-EPMC4991496 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Hsu Tsung-I TI Wang Yi-Chang YC Hung Chia-Yang CY Yu Chun-Hui CH Su Wu-Chou WC Chang Wen-Chang WC Hung Jan-Jong JJ
Oncotarget 20160401 15
The role of IL10 in the tumorigenesis of various cancer types is still controversial. Here, we found that increased IL10 levels are correlated with a poor prognosis in lung cancer patients. Moreover, IL10 levels were significantly increased in the lungs and serum of EGFRL858R- and Kras4bG12D-induced lung cancer mice, indicating that IL10 might facilitate lung cancer tumorigenesis. IL10 knockout in EGFRL858R and Kras4bG12D mice inhibited the development of lung tumors and decreased the levels of ...[more]