Ontology highlight
ABSTRACT:
SUBMITTER: Singh JC
PROVIDER: S-EPMC4991772 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Singh Jasmeet Chadha JC Lichtman Stuart M SM
Drugs & aging 20151201 12
The HER2 gene is overexpressed in 15-20 % of all breast cancers. With the advent of HER2-directed therapies, HER2 overexpression is no longer considered an adverse prognostic factor. Despite significant improvements in clinical outcomes with the use of trastuzumab [herceptin (H)], women aged >65 years remain under-represented in most clinical trials. Cardiac safety in the elderly woman is a major concern because of pre-existing comorbidities. However, many studies suggest that elderly patients w ...[more]