Ontology highlight
ABSTRACT:
SUBMITTER: Adhikari AA
PROVIDER: S-EPMC4992432 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Adhikari Arijit A AA Chisholm John D JD
Organic letters 20160803 16
The pyrroloindoline core is found in many natural products. These structures often differ at the C3a position, which may be substituted with an oxygen, nitrogen, or sp(3)- or sp(2)-hybridized carbon. Utilizing a trichloroacetimidate leaving group, a diversity-oriented approach to these structures has been developed. The trichloroacetimidate intermediate allows for the rapid incorporation of anilines, alcohols, thiols, and carbon nucleophiles. This method was applied in the synthesis of arundinin ...[more]