Ontology highlight
ABSTRACT:
SUBMITTER: Rocha NP
PROVIDER: S-EPMC4992798 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Rocha Natalia P NP Ribeiro Fabiola M FM Furr-Stimming Erin E Teixeira Antonio L AL
Mediators of inflammation 20160808
Huntington's disease (HD) is a neurodegenerative disorder characterized by selective loss of neurons in the striatum and cortex, which leads to progressive motor dysfunction, cognitive decline, and psychiatric disorders. Although the cause of HD is well described-HD is a genetic disorder caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin (HTT) on chromosome 4p16.3-the ultimate cause of neuronal death is still uncertain. Apart from impairment in systems for handl ...[more]