Integrated application of transcriptomics and metabolomics yields insights into population-asynchronous ovary development in Coilia nasus.

ABSTRACT: Populations of Coilia nasus demonstrate asynchronous ovarian development, which severely restricts artificial breeding and large-scale cultivation. In this study, we used a combination of transcriptomic and metabolomic methods to identify the key signaling pathways and genes regulation affecting ovarian development. We identified 565 compounds and generated 47,049 unigenes from ovary tissue. Fifteen metabolites and 830 genes were significantly up-regulated, while 27 metabolites and 642 genes were significantly down-regulated from stage III to stage IV of ovary development. Meanwhile, 31 metabolites and 1,932 genes were significantly up-regulated, and four metabolites and 764 genes were down-regulated from stage IV to stage V. These differentially expressed genes and metabolites were enrich

SUBMITTER: Xu G 

PROVIDER: S-EPMC4992829 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature