West Nile Virus Temperature Sensitivity and Avian Virulence Are Modulated by NS1-2B Polymorphisms.
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ABSTRACT:
SUBMITTER: Dietrich EA
PROVIDER: S-EPMC4993437 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
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West Nile Virus Temperature Sensitivity and Avian Virulence Are Modulated by NS1-2B Polymorphisms.
Dietrich Elizabeth A EA Langevin Stanley A SA Huang Claire Y-H CY Maharaj Payal D PD Delorey Mark J MJ Bowen Richard A RA Kinney Richard M RM Brault Aaron C AC
PLoS neglected tropical diseases 20160822 8
West Nile virus (WNV) replicates in a wide variety of avian species, which serve as reservoir and amplification hosts. WNV strains isolated in North America, such as the prototype strain NY99, elicit a highly pathogenic response in certain avian species, notably American crows (AMCRs; Corvus brachyrhynchos). In contrast, a closely related strain, KN3829, isolated in Kenya, exhibits a low viremic response with limited mortality in AMCRs. Previous work has associated the difference in pathogenicit ...[more]
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