Ontology highlight
ABSTRACT:
SUBMITTER: Schreiter T
PROVIDER: S-EPMC4994032 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Schreiter Thomas T Sowa Jan-Peter JP Schlattjan Martin M Treckmann Jürgen J Paul Andreas A Strucksberg Karl-Heinz KH Baba Hideo A HA Odenthal Margarete M Gieseler Robert K RK Gerken Guido G Arteel Gavin E GE Canbay Ali A
Scientific reports 20160823
Reliable test systems to identify hepatotoxicity are essential to predict unexpected drug-related liver injury. Here we present a human ex-vivo liver model to investigate acetaminophen-induced liver injury. Human liver tissue was perfused over a 30 hour period with hourly sampling from the perfusate for measurement of general metabolism and clinical parameters. Liver function was assessed by clearance of indocyanine green (ICG) at 4, 20 and 28 hours. Six pieces of untreated human liver specimen ...[more]