Ontology highlight
ABSTRACT: Background
Amongst Sardinians the human leukocyte antigen (HLA) DRB1-DQB1 haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for multiple sclerosis (MS), while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis (MAP) are predisposing factors. We studied the correlation between MAP and HLA.Methods
Five hundred thirty-one patients were searched for anti-MAP2694 antibodies, DRB1-DQB1 genotyping was performed. The haplotypes were classified as predisposing, neutral or protective.Results
Anti-MAP2694 were found in 23 % of subjects carrying one protective HLA versus 32 % without (p?=?0.04).Conclusions
We showed a lower frequency of Abs in patients with protective HLA. These haplotypes could have a protective role for both MS and MAP.
SUBMITTER: Frau J
PROVIDER: S-EPMC4994163 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Frau J J Cossu D D Sardu C C Mameli G G Coghe G G Lorefice L L Fenu G G Tranquilli S S Sechi L A LA Marrosu M G MG Cocco E E
BMC neurology 20160823 1
<h4>Background</h4>Amongst Sardinians the human leukocyte antigen (HLA) DRB1-DQB1 haplotypes *15:02-*06:01, *16:01-*05:02, *14:01-4-*05:03 are protective for multiple sclerosis (MS), while *13:03-*03:01, *04:05-*03:01, *03:01-*02:01, *15:01-*06:02 and Mycobacterium avium subspecies paratubercolosis (MAP) are predisposing factors. We studied the correlation between MAP and HLA.<h4>Methods</h4>Five hundred thirty-one patients were searched for anti-MAP2694 antibodies, DRB1-DQB1 genotyping was perf ...[more]