An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.
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ABSTRACT:
SUBMITTER: Atapattu L
PROVIDER: S-EPMC4995075 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.
Atapattu Lakmali L Saha Nayanendu N Chheang Chanly C Eissman Moritz F MF Xu Kai K Vail Mary E ME Hii Linda L Llerena Carmen C Liu Zhanqi Z Horvay Katja K Abud Helen E HE Kusebauch Ulrike U Moritz Robert L RL Ding Bi-Sen BS Cao Zhongwei Z Rafii Shahin S Ernst Matthias M Scott Andrew M AM Nikolov Dimitar B DB Lackmann Martin M Janes Peter W PW
The Journal of experimental medicine 20160808 9
The transmembrane metalloprotease ADAM10 sheds a range of cell surface proteins, including ligands and receptors of the Notch, Eph, and erbB families, thereby activating signaling pathways critical for tumor initiation and maintenance. ADAM10 is thus a promising therapeutic target. Although widely expressed, its activity is normally tightly regulated. We now report prevalence of an active form of ADAM10 in tumors compared with normal tissues, in mouse models and humans, identified by our conform ...[more]
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