Ontology highlight
ABSTRACT:
SUBMITTER: Chopra M
PROVIDER: S-EPMC4995078 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Chopra Martin M Biehl Marlene M Steinfatt Tim T Brandl Andreas A Kums Juliane J Amich Jorge J Vaeth Martin M Kuen Janina J Holtappels Rafaela R Podlech Jürgen J Mottok Anja A Kraus Sabrina S Jordán-Garrote Ana-Laura AL Bäuerlein Carina A CA Brede Christian C Ribechini Eliana E Fick Andrea A Seher Axel A Polz Johannes J Ottmüller Katja J KJ Baker Jeanette J Nishikii Hidekazu H Ritz Miriam M Mattenheimer Katharina K Schwinn Stefanie S Winter Thorsten T Schäfer Viktoria V Krappmann Sven S Einsele Hermann H Müller Thomas D TD Reddehase Matthias J MJ Lutz Manfred B MB Männel Daniela N DN Berberich-Siebelt Friederike F Wajant Harald H Beilhack Andreas A
The Journal of experimental medicine 20160815 9
Donor CD4(+)Foxp3(+) regulatory T cells (T reg cells) suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (HCT [allo-HCT]). Current clinical study protocols rely on the ex vivo expansion of donor T reg cells and their infusion in high numbers. In this study, we present a novel strategy for inhibiting GvHD that is based on the in vivo expansion of recipient T reg cells before allo-HCT, exploiting the crucial role of tumor necrosis factor receptor 2 ( ...[more]