Ontology highlight
ABSTRACT:
SUBMITTER: Liu WH
PROVIDER: S-EPMC4995083 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20160801 9
MicroRNA (miRNA) deficiency impairs the generation of T follicular helper (Tfh) cells, but the contribution of individual miRNAs to this phenotype remains poorly understood. In this study, we performed deep sequencing analysis of miRNAs expressed in Tfh cells and identified a five-miRNA signature. Analyses of mutant mice deficient of these miRNAs revealed that miR-22 and miR-183/96/182 are dispensable, but miR-155 is essential for the generation and function of Tfh cells. miR-155 deficiency led ...[more]