Ontology highlight
ABSTRACT:
SUBMITTER: Drews A
PROVIDER: S-EPMC4995397 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20160824
Local delivery of amyloid beta oligomers from the tip of a nanopipette, controlled over the cell surface, has been used to deliver physiological picomolar oligomer concentrations to primary astrocytes or neurons. Calcium influx was observed when as few as 2000 oligomers were delivered to the cell surface. When the dosing of oligomers was stopped the intracellular calcium returned to basal levels or below. Calcium influx was prevented by the presence in the pipette of the extracellular chaperone ...[more]