Oestradiol synthesized by female neurons generates sex differences in neuritogenesis.
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ABSTRACT:
SUBMITTER: Ruiz-Palmero I
PROVIDER: S-EPMC4995407 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
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Oestradiol synthesized by female neurons generates sex differences in neuritogenesis.
Ruiz-Palmero Isabel I Ortiz-Rodriguez Ana A Melcangi Roberto Cosimo RC Caruso Donatella D Garcia-Segura Luis M LM Rune Gabriele M GM Arevalo Maria-Angeles MA
Scientific reports 20160824
Testosterone produced by the foetal testis is converted by male neurons to oestradiol, which masculinizes neuronal morphology. Female neurons are known to synthesize oestradiol in absence of exogenous testosterone. However, the role of neuronal oestradiol on the differentiation of foetal female neurons is unknown. Here we show that, due to endogenous neuronal oestradiol synthesis, female hippocampal neurons have higher expression of the neuritogenic protein Neurogenin 3 and enhanced neuritogenes ...[more]
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