Ontology highlight
ABSTRACT:
SUBMITTER: Meng Y
PROVIDER: S-EPMC4995974 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Meng Yilin Y Shukla Diwakar D Pande Vijay S VS Roux Benoît B
Proceedings of the National Academy of Sciences of the United States of America 20160801 33
Nonreceptor tyrosine kinases of the Src family are large multidomain allosteric proteins that are crucial to cellular signaling pathways. In a previous study, we generated a Markov state model (MSM) to simulate the activation of c-Src catalytic domain, used as a prototypical tyrosine kinase. The long-time kinetics of transition predicted by the MSM was in agreement with experimental observations. In the present study, we apply the framework of transition path theory (TPT) to the previously const ...[more]