Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010.
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ABSTRACT: Background
There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada.Methods
We studied HIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21%) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed incident OIs among the remaining 63 541 persons, most of whom received antiretroviral therapy during the observation. We calculated incidence rates per 100 person-years of observation (hereafter, "person-years") with 95% confidence intervals (CIs) for the first occurrence of any OI and select individual OIs during 2000-2003, 2004-2007, and 2008-2010.Results
A total of 63 541 persons contributed 261 573 person-years, of whom 5836 (9%) developed at least 1 OI. The incidence rate of any first OI decreased over the 3 observation periods, with 3.0 cases, 2.4 cases, and 1.5 cases per 100 person-years of observation during 2000-2003, 2004-2007, and 2008-2010, respectively (Ptrend<.001); the rates of most individual OIs decreased as well. During 2008-2010, the leading OIs included Pneumocystis jiroveci pneumonia, esophageal candidiasis, and disseminated Mycobacterium avium complex or Mycobacterium kansasii infection.Conclusions
For HIV-infected persons in care during 2000-2010, rates of first OI were relatively low and generally declined over this time.
SUBMITTER: Buchacz K
PROVIDER: S-EPMC4996145 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010.
Buchacz Kate K Lau Bryan B Jing Yuezhou Y Bosch Ronald R Abraham Alison G AG Gill M John MJ Silverberg Michael J MJ Goedert James J JJ Sterling Timothy R TR Althoff Keri N KN Martin Jeffrey N JN Burkholder Greer G Gandhi Neel N Samji Hasina H Patel Pragna P Rachlis Anita A Thorne Jennifer E JE Napravnik Sonia S Henry Keith K Mayor Angel A Gebo Kelly K Gange Stephen J SJ Moore Richard D RD Brooks John T JT
The Journal of infectious diseases 20160418 6
<h4>Background</h4>There are few recent data on the rates of AIDS-defining opportunistic infections (OIs) among human immunodeficiency virus (HIV)-infected patients in care in the United States and Canada.<h4>Methods</h4>We studied HIV-infected participants in 16 cohorts in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) during 2000-2010. After excluding 16 737 (21%) with any AIDS-defining clinical events documented before NA-ACCORD enrollment, we analyzed inciden ...[more]
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