Perturbed meibomian gland and tarsal plate morphogenesis by excess TGF? in eyelid stroma.

ABSTRACT: Transforming growth factor alpha (TGF?) belongs to the epidermal growth factor (EGF) family and is known to play an important role during eyelid morphogenesis. In this study, we showed that ectopic expression of TGF? in the stroma of Kera-rtTA/tet-O-TGF? bitransgenic mice results in precocious eye opening, abnormal morphogenesis of the meibomian gland, tendon and tarsal plate malformation and epithelium hyperplasia. TGF? did not change proliferation and differentiation of meibocytes, but promoted proliferation and inhibited differentiation of the tarsal plate tenocytes. These results suggest that proper formation of the tendon and tarsal plate in the mouse eyelid is required for normal morphogenesis of the meibomian gland.

SUBMITTER: Dong F 

PROVIDER: S-EPMC4996271 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature