Perturbed meibomian gland and tarsal plate morphogenesis by excess TGF? in eyelid stroma.
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ABSTRACT:
SUBMITTER: Dong F
PROVIDER: S-EPMC4996271 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma.
Dong Fei F Liu Chia-Yang CY Yuan Yong Y Zhang Yujin Y Li Wei W Call Mindy M Zhang Liyun L Chen Yongxiong Y Liu Zuguo Z Kao Winston W Y WW
Developmental biology 20150910 2
Transforming growth factor alpha (TGFα) belongs to the epidermal growth factor (EGF) family and is known to play an important role during eyelid morphogenesis. In this study, we showed that ectopic expression of TGFα in the stroma of Kera-rtTA/tet-O-TGFα bitransgenic mice results in precocious eye opening, abnormal morphogenesis of the meibomian gland, tendon and tarsal plate malformation and epithelium hyperplasia. TGFα did not change proliferation and differentiation of meibocytes, but promote ...[more]
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