Ontology highlight
ABSTRACT:
SUBMITTER: Banerjee S
PROVIDER: S-EPMC4996771 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Banerjee S S Sindberg G G Wang F F Meng J J Sharma U U Zhang L L Dauer P P Chen C C Dalluge J J Johnson T T Roy S S
Mucosal immunology 20160224 6
Morphine and its pharmacological derivatives are the most prescribed analgesics for moderate to severe pain management. However, chronic use of morphine reduces pathogen clearance and induces bacterial translocation across the gut barrier. The enteric microbiome has been shown to have a critical role in the preservation of the mucosal barrier function and metabolic homeostasis. Here, we show for the first time, using bacterial 16s rDNA sequencing, that chronic morphine treatment significantly al ...[more]