Ontology highlight
ABSTRACT:
SUBMITTER: Sieberts SK
PROVIDER: S-EPMC4996969 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Sieberts Solveig K SK Zhu Fan F García-García Javier J Stahl Eli E Pratap Abhishek A Pandey Gaurav G Pappas Dimitrios D Aguilar Daniel D Anton Bernat B Bonet Jaume J Eksi Ridvan R Fornés Oriol O Guney Emre E Li Hongdong H Marín Manuel Alejandro MA Panwar Bharat B Planas-Iglesias Joan J Poglayen Daniel D Cui Jing J Falcao Andre O AO Suver Christine C Hoff Bruce B Balagurusamy Venkat S K VSK Dillenberger Donna D Neto Elias Chaibub EC Norman Thea T Aittokallio Tero T Ammad-Ud-Din Muhammad M Azencott Chloe-Agathe CA Bellón Víctor V Boeva Valentina V Bunte Kerstin K Chheda Himanshu H Cheng Lu L Corander Jukka J Dumontier Michel M Goldenberg Anna A Gopalacharyulu Peddinti P Hajiloo Mohsen M Hidru Daniel D Jaiswal Alok A Kaski Samuel S Khalfaoui Beyrem B Khan Suleiman Ali SA Kramer Eric R ER Marttinen Pekka P Mezlini Aziz M AM Molparia Bhuvan B Pirinen Matti M Saarela Janna J Samwald Matthias M Stoven Véronique V Tang Hao H Tang Jing J Torkamani Ali A Vert Jean-Phillipe JP Wang Bo B Wang Tao T Wennerberg Krister K Wineinger Nathan E NE Xiao Guanghua G Xie Yang Y Yeung Rae R Zhan Xiaowei X Zhao Cheng C Greenberg Jeff J Kremer Joel J Michaud Kaleb K Barton Anne A Coenen Marieke M Mariette Xavier X Miceli Corinne C Shadick Nancy N Weinblatt Michael M de Vries Niek N Tak Paul P PP Gerlag Danielle D Huizinga Tom W J TWJ Kurreeman Fina F Allaart Cornelia F CF Louis Bridges S S Criswell Lindsey L Moreland Larry L Klareskog Lars L Saevarsdottir Saedis S Padyukov Leonid L Gregersen Peter K PK Friend Stephen S Plenge Robert R Stolovitzky Gustavo G Oliva Baldo B Guan Yuanfang Y Mangravite Lara M LM
Nature communications 20160823
Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, treatment fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment of the utility of SNP data for predicting anti-TNF treatment efficacy in RA patients was performed in the context of a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled the ...[more]