Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex.
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ABSTRACT:
SUBMITTER: Kuhn M
PROVIDER: S-EPMC4996971 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex.
Kuhn Marion M Wolf Elias E Maier Jonathan G JG Mainberger Florian F Feige Bernd B Schmid Hanna H Bürklin Jan J Maywald Sarah S Mall Volker V Jung Nikolai H NH Reis Janine J Spiegelhalder Kai K Klöppel Stefan S Sterr Annette A Eckert Anne A Riemann Dieter D Normann Claus C Nissen Christoph C
Nature communications 20160823
Sleep is ubiquitous in animals and humans, but its function remains to be further determined. The synaptic homeostasis hypothesis of sleep-wake regulation proposes a homeostatic increase in net synaptic strength and cortical excitability along with decreased inducibility of associative synaptic long-term potentiation (LTP) due to saturation after sleep deprivation. Here we use electrophysiological, behavioural and molecular indices to non-invasively study net synaptic strength and LTP-like plast ...[more]
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