Unknown

Dataset Information

0

Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex.


ABSTRACT: Sleep is ubiquitous in animals and humans, but its function remains to be further determined. The synaptic homeostasis hypothesis of sleep-wake regulation proposes a homeostatic increase in net synaptic strength and cortical excitability along with decreased inducibility of associative synaptic long-term potentiation (LTP) due to saturation after sleep deprivation. Here we use electrophysiological, behavioural and molecular indices to non-invasively study net synaptic strength and LTP-like plasticity in humans after sleep and sleep deprivation. We demonstrate indices of increased net synaptic strength (TMS intensity to elicit a predefined amplitude of motor-evoked potential and EEG theta activity) and decreased LTP-like plasticity (paired associative stimulation induced change in motor-evoked potential and memory formation) after sleep deprivation. Changes in plasma BDNF are identified as a potential mechanism. Our study indicates that sleep recalibrates homeostatic and associative synaptic plasticity, believed to be the neural basis for adaptive behaviour, in humans.

SUBMITTER: Kuhn M 

PROVIDER: S-EPMC4996971 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5727212 | biostudies-literature
| S-EPMC3136313 | biostudies-other
| S-EPMC8187282 | biostudies-literature
| S-EPMC3657766 | biostudies-literature
| S-EPMC4133507 | biostudies-literature
| S-EPMC4020085 | biostudies-other
| S-EPMC5907800 | biostudies-literature
| S-EPMC2634746 | biostudies-literature
| S-EPMC5299565 | biostudies-other
| S-EPMC3782631 | biostudies-literature