Cognitive phenotypes in childhood idiopathic epilepsies.

ABSTRACT:

Objective

The objective of this study was to identify cognitive phenotypes in children with new-onset focal and generalized idiopathic epilepsies and determine their relationship with epilepsy syndrome, brain structure, neurodevelopmental history, and family characteristics.

Methods

One hundred thirty-eight children with new-onset epilepsy and 95 controls (age: 8-18) underwent neuropsychological, clinical, and quantitative MR evaluations. Control participants' neuropsychological data were subjected to confirmatory factor analysis and then resultant factor scores were applied to participants with epilepsy and subjected to latent class analysis. Identified cognitive phenotypes were examined in relation to epilepsy syndrome, quantitative neuroimaging, and familial and neurodeve

SUBMITTER: Hermann BP 

PROVIDER: S-EPMC4998056 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature