Ontology highlight
ABSTRACT:
SUBMITTER: Kostich W
PROVIDER: S-EPMC4998676 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kostich Walter W Hamman Brian D BD Li Yu-Wen YW Naidu Sreenivasulu S Dandapani Kumaran K Feng Jianlin J Easton Amy A Bourin Clotilde C Baker Kevin K Allen Jason J Savelieva Katerina K Louis Justin V JV Dokania Manoj M Elavazhagan Saravanan S Vattikundala Pradeep P Sharma Vivek V Das Manish Lal ML Shankar Ganesh G Kumar Anoop A Holenarsipur Vinay K VK Gulianello Michael M Molski Ted T Brown Jeffrey M JM Lewis Martin M Huang Yanling Y Lu Yifeng Y Pieschl Rick R O'Malley Kevin K Lippy Jonathan J Nouraldeen Amr A Lanthorn Thomas H TH Ye Guilan G Wilson Alan A Balakrishnan Anand A Denton Rex R Grace James E JE Lentz Kimberley A KA Santone Kenneth S KS Bi Yingzhi Y Main Alan A Swaffield Jon J Carson Ken K Mandlekar Sandhya S Vikramadithyan Reeba K RK Nara Susheel J SJ Dzierba Carolyn C Bronson Joanne J Macor John E JE Zaczek Robert R Westphal Ryan R Kiss Laszlo L Bristow Linda L Conway Charles M CM Zambrowicz Brian B Albright Charles F CF
The Journal of pharmacology and experimental therapeutics 20160713 3
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute and persistent pain behavior assays. One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) gene, had a normal response in acute pain assays (hot plate, phase I formalin), but a markedly reduced response to persistent pain in phase II formalin. AAK1 knockout mice also failed to develop tactile allodynia following the Chung procedure of spina ...[more]