Ontology highlight
ABSTRACT:
SUBMITTER: Pacardo DB
PROVIDER: S-EPMC4998739 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Pacardo Dennis B DB Neupane Bhanu B Rikard S Michaela SM Lu Yue Y Mo Ran R Mishra Sumeet R SR Tracy Joseph B JB Wang Gufeng G Ligler Frances S FS Gu Zhen Z
Nanoscale 20150630 28
A multifunctional gold nanorod (AuNR) complex is described with potential utility for theranostic anticancer treatment. The AuNR was functionalized with cyclodextrin for encapsulation of doxorubicin, with folic acid for targeting, and with a photo-responsive dextran-azo compound for intracellular controlled drug release. The interaction of a AuNR complex with HeLa cells was facilitated via a folic acid targeting ligand as displayed in the dark-field images of cells. Enhanced anticancer efficacy ...[more]