Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery.
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ABSTRACT:
SUBMITTER: Ye Y
PROVIDER: S-EPMC4998837 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Microneedles Integrated with Pancreatic Cells and Synthetic Glucose-Signal Amplifiers for Smart Insulin Delivery.
Ye Yanqi Y Yu Jicheng J Wang Chao C Nguyen Nhu-Y NY Walker Glenn M GM Buse John B JB Gu Zhen Z
Advanced materials (Deerfield Beach, Fla.) 20160301 16
An innovative microneedle (MN)-based cell therapy is developed for glucose-responsive regulation of the insulin secretion from exogenous pancreatic β-cells without implantation. One MN patch can quickly reduce the blood-sugar levels (BGLs) of chemically induced type-1 diabetic mice and stabilize BGLs at a reduced level for over 10 h. ...[more]
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