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Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy.

ABSTRACT: A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen ((1) O2 ) and inducing hypoxia to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. This dual-responsive nanocarrier provides an innovative design guideline for enhancing traditional photodynamic therapeutic efficacy integrated with a controlled drug-release modality.

SUBMITTER: Qian C

PROVIDER: S-EPMC4998838 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy.

Qian Chenggen C Yu Jicheng J Chen Yulei Y Hu Quanyin Q Xiao Xuanzhong X Sun Wujin W Wang Chao C Feng Peijian P Shen Qun-Dong QD Gu Zhen Z

Advanced materials (Deerfield Beach, Fla.) 20160307 17

A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen ((1) O2 ) and inducing hypoxia to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. This dual-responsive nanocarrier provides an innovative design guideline for enhancing traditional photodynamic therapeutic efficacy integrated with a controlled drug-release modality. ...[more]

PMID: 26948067

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