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ABSTRACT: Background
Cross-sectional studies suggest that the serotonin transporter promoter region polymorphism (5-HTT gene-linked polymorphic region, 5HTTLPR) moderates the relationship between childhood abuse and major depressive disorder.Aims
To examine whether the 5HTTLPR polymorphism moderates the effect childhood abuse has on 5-year depressive symptom severity trajectories in adulthood.Method
At 5-year follow-up, DNA from 333 adult primary care attendees was obtained and genotyped for the 5HTTLPR polymorphism. Linear mixed models were used to test for a genotype × childhood abuse interaction effect on 5-year depressive symptom severity trajectories.Results
After covariate adjustment, homozygous s allele carriers with a history of severe childhood abuse had significantly greater depressive symptom severity at baseline compared with those without a history of severe childhood abuse and this effect persisted throughout the 5-year period of observation.Conclusions
The 5HTTLPR s/s genotype robustly moderates the effects of severe childhood abuse on depressive symptom severity trajectories in adulthood.Declaration of interest
None.Copyright and usage
© The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
SUBMITTER: Nguyen TB
PROVIDER: S-EPMC4998927 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Nguyen Timothy B TB Gunn Jane M JM Potiriadis Maria M Everall Ian P IP Bousman Chad A CA
BJPsych open 20150601 1
<h4>Background</h4>Cross-sectional studies suggest that the serotonin transporter promoter region polymorphism (5-HTT gene-linked polymorphic region, <i>5HTTLPR</i>) moderates the relationship between childhood abuse and major depressive disorder.<h4>Aims</h4>To examine whether the <i>5HTTLPR</i> polymorphism moderates the effect childhood abuse has on 5-year depressive symptom severity trajectories in adulthood.<h4>Method</h4>At 5-year follow-up, DNA from 333 adult primary care attendees was ob ...[more]