Ontology highlight
ABSTRACT:
SUBMITTER: Ramo K
PROVIDER: S-EPMC4999312 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Ramo Kasmir K Sugamura Koichi K Craige Siobhan S Keaney John F JF Davis Roger J RJ
eLife 20160809
Arterial occlusive diseases are major causes of morbidity and mortality. Blood flow to the affected tissue must be restored quickly if viability and function are to be preserved. We report that disruption of the mixed-lineage protein kinase (MLK) - cJun NH2-terminal kinase (JNK) signaling pathway in endothelial cells causes severe blockade of blood flow and failure to recover in the murine femoral artery ligation model of hindlimb ischemia. We show that the MLK-JNK pathway is required for the fo ...[more]