Ontology highlight
ABSTRACT:
SUBMITTER: Kandaswamy R
PROVIDER: S-EPMC4999417 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Cell reports 20160811 8
Chronic lymphocytic leukemia (CLL) is an adult B cell malignancy. Genome-wide association studies show that variation at 15q15.1 influences CLL risk. We deciphered the causal variant at 15q15.1 and the mechanism by which it influences tumorigenesis. We imputed all possible genotypes across the locus and then mapped highly associated SNPs to areas of chromatin accessibility, evolutionary conservation, and transcription factor binding. SNP rs539846 C>A, the most highly associated variant (p = 1.42 ...[more]