Ontology highlight
ABSTRACT:
SUBMITTER: Boelens MC
PROVIDER: S-EPMC4999419 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Boelens Mirjam C MC Nethe Micha M Klarenbeek Sjoerd S de Ruiter Julian R JR Schut Eva E Bonzanni Nicola N Zeeman Amber L AL Wientjens Ellen E van der Burg Eline E Wessels Lodewyk L van Amerongen Renée R Jonkers Jos J
Cell reports 20160811 8
Invasive lobular carcinoma (ILC) is an aggressive breast cancer subtype with poor response to chemotherapy. Besides loss of E-cadherin, a hallmark of ILC, genetic inactivation of PTEN is frequently observed in patients. Through concomitant Cre-mediated inactivation of E-cadherin and PTEN in mammary epithelium, we generated a mouse model of classical ILC (CLC), the main histological ILC subtype. While loss of E-cadherin induced cell dissemination and apoptosis, additional PTEN inactivation promot ...[more]