Ontology highlight
ABSTRACT:
SUBMITTER: Zhuang Q
PROVIDER: S-EPMC4999515 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Zhuang Quan Q Liu Quan Q Divito Sherrie J SJ Zeng Qiang Q Yatim Karim M KM Hughes Andrew D AD Rojas-Canales Darling M DM Nakao A A Shufesky William J WJ Williams Amanda L AL Humar Rishab R Hoffman Rosemary A RA Shlomchik Warren D WD Oberbarnscheidt Martin H MH Lakkis Fadi G FG Morelli Adrian E AE
Nature communications 20160824
Successful engraftment of organ transplants has traditionally relied on preventing the activation of recipient (host) T cells. Once T-cell activation has occurred, however, stalling the rejection process becomes increasingly difficult, leading to graft failure. Here we demonstrate that graft-infiltrating, recipient (host) dendritic cells (DCs) play a key role in driving the rejection of transplanted organs by activated (effector) T cells. We show that donor DCs that accompany heart or kidney gra ...[more]