Ontology highlight
ABSTRACT:
SUBMITTER: Doobin DJ
PROVIDER: S-EPMC4999518 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Doobin David J DJ Kemal Shahrnaz S Dantas Tiago J TJ Vallee Richard B RB
Nature communications 20160824
Microcephaly is a cortical malformation disorder characterized by an abnormally small brain. Recent studies have revealed severe cases of microcephaly resulting from human mutations in the NDE1 gene, which is involved in the regulation of cytoplasmic dynein. Here using in utero electroporation of NDE1 short hairpin RNA (shRNA) in embryonic rat brains, we observe cell cycle arrest of proliferating neural progenitors at three distinct stages: during apical interkinetic nuclear migration, at the G2 ...[more]