Is the Mouse a Good Model of Human PPAR?-Related Metabolic Diseases?
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ABSTRACT:
SUBMITTER: Pap A
PROVIDER: S-EPMC5000634 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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Is the Mouse a Good Model of Human PPARγ-Related Metabolic Diseases?
Pap Attila A Cuaranta-Monroy Ixchelt I Peloquin Matthew M Nagy Laszlo L
International journal of molecular sciences 20160730 8
With the increasing number of patients affected with metabolic diseases such as type 2 diabetes, obesity, atherosclerosis and insulin resistance, academic researchers and pharmaceutical companies are eager to better understand metabolic syndrome and develop new drugs for its treatment. Many studies have focused on the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ), which plays a crucial role in adipogenesis and lipid metabolism. These studies have been able to connect ...[more]
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