Ontology highlight
ABSTRACT:
SUBMITTER: Marshall SS
PROVIDER: S-EPMC5001948 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Marshall Stephen S SS Niesen Michiel J M MJM Müller Axel A Tiemann Katrin K Saladi Shyam M SM Galimidi Rachel P RP Zhang Bin B Clemons William M WM Miller Thomas F TF
Cell reports 20160811 8
Integral membrane proteins (IMPs) control the flow of information and nutrients across cell membranes, yet IMP mechanistic studies are hindered by difficulties in expression. We investigate this issue by addressing the connection between IMP sequence and observed expression levels. For homologs of the IMP TatC, observed expression levels vary widely and are affected by small changes in protein sequence. The effect of sequence changes on experimentally observed expression levels strongly correlat ...[more]