Dataset Information

The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis.

ABSTRACT:

Background

The role of human papilloma virus (HPV) in oral lichen planus (OLP) is controversial.

Objectives

The primary aim of the current study is to calculate the pooled risk estimates of HPV infection in OLP when compared with healthy controls.

Methods

Bibliographic searches were conducted in three electronic databases. Articles on the association between HPV and OLP were selected from case-control studies or cross-sectional studies, following predefined criteria. Pooled data were analyzed by calculating odds ratios (OR) and 95% confidence interval (CI).

Results

Of the 233 publications identified, 22 case-control studies met the inclusion criteria. Collectively, 835 cases and 734 controls were available for analysis. The summary estimate showed that OLP patients have significantly higher HPV prevalence (OR: 6.83; 95% CI: 4.15-11.27) than healthy controls. In subgroup analyses, the association of HPV and OLP varied significantly by geographic populations. The ORs ranged from 2.43 to 132.04. The correlation of HPV and erosive-atrophic oral lichen planus (EA-OLP) (OR: 9.34) was comparable and well above that of HPV and non-EA-OLP (OR: 4.32). Among HPV genotypes, HPV 16 showed an extremely strong association with OLP (OR: 11.27), and HPV 18 showed a relatively strong one (OR: 6.54).

Conclusion

In conclusion, a significant association was found between HPV and OLP. The strength of the association varied across geographic populations, clinical types of OLP, and HPV genotypes. The results suggest that HPV might play an important causal role in OLP and in its malignant to progression.

SUBMITTER: Ma J

PROVIDER: S-EPMC5003373 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis.

Ma Junxian J Zhang Jinshan J Zhang Yan Y Lv Tingting T Liu Jie J

PloS one 20160829 8

<h4>Background</h4>The role of human papilloma virus (HPV) in oral lichen planus (OLP) is controversial.<h4>Objectives</h4>The primary aim of the current study is to calculate the pooled risk estimates of HPV infection in OLP when compared with healthy controls.<h4>Methods</h4>Bibliographic searches were conducted in three electronic databases. Articles on the association between HPV and OLP were selected from case-control studies or cross-sectional studies, following predefined criteria. Pooled ...[more]

PMID: 27571417

Similar Datasets

Project description:ImportanceIntegrated information on the global prevalence and incidence of oral lichen planus (OLP) is lacking.ObjectiveTo examine the global prevalence and incidence of OLP in a systematic review and meta-analysis.Data sourcesA systematic review of population-based studies and clinic-based studies reporting the prevalence and incidence of OLP was performed using 3 electronic medical databases (Cochrane Database of Systematic Reviews, Embase, and MEDLINE) from their inception to March 2019. The search terms included "(lichen planus or LP) and (prevalence or incidence or epidemiology)." No language restriction was applied.Study selectionObservational descriptive studies investigating the prevalence and incidence of OLP were included.Data extraction and synthesisData were extracted by continent, sex, and other characteristics. The risk of bias was assessed by the Joanna Briggs Institute Critical Appraisal Instrument for Studies Reporting Prevalence Data using random-effects models to synthesize available evidence.Main outcomes and measuresThe primary outcome was the prevalence (with 95% CIs) of OLP among the overall population and among subgroups. Between-study heterogeneity was assessed using the I2 statistic.ResultsAmong 46 studies, the overall pooled estimated prevalence of OLP was 0.89% (95% CI, 0.38%-2.05%) among the general population (n = 462 993) and 0.98% (95% CI, 0.67%-1.43%) among clinical patients (n = 191 963). Among the 15 population-based studies, the prevalence of OLP was 0.57% (95% CI, 0.15%-2.18%) in Asia, 1.68% (95% CI, 1.09%-2.58%) in Europe, and 1.39% (95% CI, 0.58%-3.28%) in South America. Among the 31 clinic-based studies, the prevalence was 1.43% (95% CI, 1.12%-1.83%) in Africa, 0.87% (95% CI, 0.61%-1.25%) in Asia, 1.03% (95% CI, 0.51%-2.09%) in Europe, 0.11% (95% CI, 0.07%-0.16%) in North America, and 3.18% (95% CI, 0.97%-9.95%) in South America. The pooled prevalence of OLP by sex was 1.55% (95% CI, 0.83%-2.89%) for women and 1.11% (95% CI, 0.57%-2.14%) for men in the population-based studies and 1.69% (95% CI, 1.05%-2.70%) for women and 1.09% (95% CI, 0.67%-1.77%) for men in the clinic-based studies. In 5 clinic-based studies providing the age distribution of patients with OLP, the prevalence by age was 0.62% (95% CI, 0.33%-1.13%) among patients younger than 40 years and 1.90% (95% CI, 1.16%-3.10%) among patients 40 years and older.Conclusions and relevanceThis study identified the global prevalence and incidence of OLP in terms of its spatial, temporal, and population distribution. The overall estimated pooled prevalence of OLP was 0.89% among the general population and 0.98% among clinical patients. A higher prevalence of OLP was found in non-Asian countries, among women, and among people 40 years and older. The findings should be considered with caution because of the high heterogeneity of the included studies.

Dataset Information

The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis.

Background

Objectives

Methods

Results

Conclusion

Publications

The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis.

Similar Datasets

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