Ontology highlight
ABSTRACT:
SUBMITTER: Petroni GR
PROVIDER: S-EPMC5003756 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Petroni Gina R GR Wages Nolan A NA Paux Gautier G Dubois Frédéric F
Statistics in medicine 20160229 2
There has been constant development of novel statistical methods in the design of early-phase clinical trials since the introduction of model-based designs, yet the traditional or modified 3+3 algorithmic design remains the most widely used approach in dose-finding studies. Research has shown the limitations of this traditional design compared with more innovative approaches yet the use of these model-based designs remains infrequent. This can be attributed to several causes including a poor und ...[more]