Deep Proteome Analysis Identifies Age-Related Processes in C. elegans.
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ABSTRACT:
SUBMITTER: Narayan V
PROVIDER: S-EPMC5003814 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Deep Proteome Analysis Identifies Age-Related Processes in C. elegans.
Narayan Vikram V Ly Tony T Pourkarimi Ehsan E Murillo Alejandro Brenes AB Gartner Anton A Lamond Angus I AI Kenyon Cynthia C
Cell systems 20160721 2
Effective network analysis of protein data requires high-quality proteomic datasets. Here, we report a near doubling in coverage of the C. elegans adult proteome, identifying >11,000 proteins in total with ∼9,400 proteins reproducibly detected in three biological replicates. Using quantitative mass spectrometry, we identify proteins whose abundances vary with age, revealing a concerted downregulation of proteins involved in specific metabolic pathways and upregulation of cellular stress response ...[more]
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