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Mitochondrial role in adaptive response to stress conditions in preeclampsia.

ABSTRACT: Preeclampsia (PE) is a pregnancy-specific syndrome, characterized in general by hypertension with proteinuria or other systemic disturbances. PE is the major cause of maternal and fetal morbidity and mortality worldwide. However, the etiology of PE still remains unclear. Our study involved 38 patients: 14 with uncomplicated pregnancy; 13 with early-onset PE (eoPE); and 11 with late-onset PE (loPE). We characterized the immunophenotype of cells isolated from the placenta and all biopsy samples were stained positive for Cytokeratin 7, SOX2, Nestin, Vimentin, and CD44. We obtained a significant increase in OPA1 mRNA and protein expression in the eoPE placentas. Moreover, TFAM expression was down-regulated in comparison to the control (p?

SUBMITTER: Vishnyakova PA

PROVIDER: S-EPMC5004102 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Mitochondrial role in adaptive response to stress conditions in preeclampsia.

Vishnyakova Polina A PA Volodina Maria A MA Tarasova Nadezhda V NV Marey Maria V MV Tsvirkun Daria V DV Vavina Olga V OV Khodzhaeva Zulfiya S ZS Kan Natalya E NE Menon Ramkumar R Vysokikh Mikhail Yu MY Sukhikh Gennady T GT

Scientific reports 20160830

Preeclampsia (PE) is a pregnancy-specific syndrome, characterized in general by hypertension with proteinuria or other systemic disturbances. PE is the major cause of maternal and fetal morbidity and mortality worldwide. However, the etiology of PE still remains unclear. Our study involved 38 patients: 14 with uncomplicated pregnancy; 13 with early-onset PE (eoPE); and 11 with late-onset PE (loPE). We characterized the immunophenotype of cells isolated from the placenta and all biopsy samples we ...[more]

PMID: 27573305

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