Ontology highlight
ABSTRACT:
SUBMITTER: Lee JH
PROVIDER: S-EPMC5004232 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Lee Ji-Hyun JH Zhao Xing-Ming XM Yoon Ina I Lee Jin Young JY Kwon Nam Hoon NH Wang Yin-Ying YY Lee Kyung-Min KM Lee Min-Joo MJ Kim Jisun J Moon Hyeong-Gon HG In Yongho Y Hao Jin-Kao JK Park Kyung-Mii KM Noh Dong-Young DY Han Wonshik W Kim Sunghoon S
Cell discovery 20160830
Despite the explosion in the numbers of cancer genomic studies, metastasis is still the major cause of cancer mortality. In breast cancer, approximately one-fifth of metastatic patients survive 5 years. Therefore, detecting the patients at a high risk of developing distant metastasis at first diagnosis is critical for effective treatment strategy. We hereby present a novel systems biology approach to identify driver mutations escalating the risk of metastasis based on both exome and RNA sequenci ...[more]