Ontology highlight
ABSTRACT:
SUBMITTER: Obenhaus HA
PROVIDER: S-EPMC5004486 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Frontiers in molecular neuroscience 20160830
The causal interrogation of neuronal networks involved in specific behaviors requires the spatially and temporally controlled modulation of neuronal activity. For long-term manipulation of neuronal activity, chemogenetic tools provide a reasonable alternative to short-term optogenetic approaches. Here we show that virus mediated gene transfer of the ivermectin (IVM) activated glycine receptor mutant GlyRα1 (AG) can be used for the selective and reversible silencing of specific neuronal networks ...[more]