Ontology highlight
ABSTRACT:
SUBMITTER: Zhou V
PROVIDER: S-EPMC5004941 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Zhou Vivian V Agle Kimberle K Chen Xiao X Beres Amy A Komorowski Richard R Belle Ludovic L Taylor Carolyn C Zhu Fenlu F Haribhai Dipica D Williams Calvin B CB Verbsky James J Blumenschein Wendy W Sadekova Svetlana S Bowman Eddie E Ballantyne Christie C Weaver Casey C Serody David A DA Vincent Benjamin B Serody Jonathan J Cua Daniel J DJ Drobyski William R WR
The Journal of clinical investigation 20160808 9
Damage to the gastrointestinal tract is a major cause of morbidity and mortality in graft-versus-host disease (GVHD) and is attributable to T cell-mediated inflammation. In this work, we identified a unique CD4+ T cell population that constitutively expresses the β2 integrin CD11c and displays a biased central memory phenotype and memory T cell transcriptional profile, innate-like properties, and increased expression of the gut-homing molecules α4β7 and CCR9. Using several complementary murine G ...[more]