Ontology highlight
ABSTRACT:
SUBMITTER: Kim M
PROVIDER: S-EPMC5004955 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Kim Minah M Allen Breanna B Korhonen Emilia A EA Nitschké Maximilian M Yang Hee Won HW Baluk Peter P Saharinen Pipsa P Alitalo Kari K Daly Christopher C Thurston Gavin G McDonald Donald M DM
The Journal of clinical investigation 20160822 9
Angiopoietin-2 (ANG2) regulates blood vessel remodeling in many pathological conditions through differential effects on Tie2 signaling. While ANG2 competes with ANG1 to inhibit Tie2, it can paradoxically also promote Tie2 phosphorylation (p-Tie2). A related paradox is that both inactivation and overactivation of Tie2 can result in vascular remodeling. Here, we reconciled these opposing actions of ANG2 by manipulating conditions that govern its actions in the vasculature. ANG2 drove vascular remo ...[more]