Ontology highlight
ABSTRACT:
SUBMITTER: Daud AI
PROVIDER: S-EPMC5004965 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Daud Adil I AI Loo Kimberly K Pauli Mariela L ML Sanchez-Rodriguez Robert R Sandoval Priscila Munoz PM Taravati Keyon K Tsai Katy K Nosrati Adi A Nardo Lorenzo L Alvarado Michael D MD Algazi Alain P AP Pampaloni Miguel H MH Lobach Iryna V IV Hwang Jimmy J Pierce Robert H RH Gratz Iris K IK Krummel Matthew F MF Rosenblum Michael D MD
The Journal of clinical investigation 20160815 9
<h4>Background</h4>Immune checkpoint blockade is revolutionizing therapy for advanced cancer, but many patients do not respond to treatment. The identification of robust biomarkers that predict clinical response to specific checkpoint inhibitors is critical in order to stratify patients and to rationally select combinations in the context of an expanding array of therapeutic options.<h4>Methods</h4>We performed multiparameter flow cytometry on freshly isolated metastatic melanoma samples from 2 ...[more]