Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury.

ABSTRACT:

Objective

To evaluate the clinical effectiveness of bolus-dose fentanyl and midazolam to treat episodic intracranial hypertension in children with severe traumatic brain injury.

Design

Retrospective cohort.

Setting

PICU in a university-affiliated children's hospital level I trauma center.

Patients

Thirty-one children 0-18 years of age with severe traumatic brain injury (Glasgow Coma Scale score of ≤ 8) who received bolus doses of fentanyl and/or midazolam for treatment of episodic intracranial hypertension.

Interventions

None.

Measurements and main results

The area under the curve from high-resolution intracranial pressure-time plots was calculated to represent cumulative intracranial hypertension exposure: area under the curve for intracranial pr

SUBMITTER: Welch TP 

PROVIDER: S-EPMC5005007 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature