Ontology highlight
ABSTRACT:
SUBMITTER: Crowe EP
PROVIDER: S-EPMC5005348 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Crowe Elizabeth P EP Tuzer Ferit F Gregory Brian D BD Donahue Greg G Gosai Sager J SJ Cohen Justin J Leung Yuk Y YY Yetkin Emre E Nativio Raffaella R Wang Li-San LS Sell Christian C Bonini Nancy M NM Berger Shelley L SL Johnson F Brad FB Torres Claudio C
Frontiers in aging neuroscience 20160831
Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging biology that may underlie these diseases is cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes in gene expression, and typically demonstrate altered, pro-inflammatory profiles. Astrocyte senescence has been implicated in neurodegenerative disease, and to better understand senescence-associated changes in astrocytes, we investigated changes in their transcriptome ...[more]